Brighton & Hove Albion's mettle will be tested when defending champions Manchester City head to Amex Stadium for a 2021/22 English Premier League match on Saturday. 

Bologna FC will go head to head with AC Milan in an Italian Serie A match at the Stadio Renato Dall'Ara on October 23. 
 

Sevilla FC will battle it out with UD Levante in a Spanish La Liga match at the Estadio Ramón Sánchez Pizjuán on October 24.

 Paris Saint Germain (PSG) will square off with RB Leipzig in an UEFA Champions League Group A match on October 19.

Newcastle United will play their first game since confirmation that a consortium led by Saudi Arabia's Public Investment Fund (PIF) had been given the go-ahead to buy the club when they host Tottenham Hotspur in a 2021/22 English Premier League match on Sunday. 

Juventus FC will face off with AS Roma in an Italian Serie A match at the Allianz Stadium on October 17.

Granada CF will square off with Atletico Madrid in a Spanish La Liga match at the Estadio Nuevo Los Cármenes on October 17.

Germany will look for revenge over North Macedonia when the teams meet in a 2022 World Cup Qualifying Group J match, set for the Tose Proeski Arena in Skopje on the evening of Monday 11 October 2021. Kick-off is at 18:45.

The Czech Republic will host Wales in a crucial Group E 2022 FIFA World Cup qualifier in Prague on Friday evening. 

Ghana will battle it out with Zimbabwe in a 2022 FIFA World Cup Qualifier - Group G match on October 09.